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EYLEA® (aflibercept) 8 mg

TREAT WITH A KNOWN MOLECULE AND SAFTY PROFILE

Safety profile

The reassurance of treating your patients with the tried-and-trusted aflibercept molecule

In PULSAR and PHOTON, EYLEA 8mg demonstrated a safety profile consistent with EYLEA 2mg from baseline through Week 96:^*

^{* EYLEA (aflibercept) 2mg was dosed at fixed Q8 intervals after 3 (nAMD) or 5 (DME) initial monthly injections.}

Safety Profile in Neovascular age-related macular degeneration (nAMD)

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Safety Profile in Diabetic macular oedema (DME)

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Dosing

Discover proactive dosing in nAMD and DME

Mechanism of Action (MoA)

Discover more about the MoA of EYLEA 8mg

Abbreviations

2Q8

^{, 2 mg every 8 weeks;}^8Q12^{, 8 mg every 12 weeks;}^8Q16^{, 8 mg every 16 weeks;}^AE^{, adverse event;}^APTC^{, Anti-Platelet Trialists’ Collaboration;}^DME^{, diabetic macular oedema;}^IOI^{, intraocular inflammation;}^IOP^{, intraocular pressure;}^MoA^{, mechanism of action;}^nAMD^{, neovascular (wet) age-related macular degeneration;}^Q8^{, every 8 weeks;}^SAE^{, serious adverse event;}^SAF^{, safety analysis set;}^TEAE^{, treatment-emergent adverse event.}

PP-EYL_8mg-IE-0155-1 | December 2025

References

1
Korobelnik J-F. Intravitreal aflibercept 8 mg injection in patients with neovascular age-related macular degeneration: 48-week results from the Phase 3 PULSAR trial. Retina Society. 2–5 November 2022. Pasadena, USA. Oral presentation.
2
Do D. Aflibercept 8 mg for diabetic macular edema: 48-week results from the Phase 2/3 PHOTON trial. ARVO. 23–27 April 2023. Palo Alto, USA. Oral presentation.
3
Korobelnik J-F. Aflibercept 8 mg in patients with neovascular age-related macular degeneration: Phase 3 PULSAR trial 96-week results. AAO. 3–6 November 2023. San Francisco, USA. Oral presentation.
4
Wykoff CC. Aflibercept 8 mg for diabetic macular edema: 96-week results from the Phase 2/3 PHOTON trial. EURETINA. 5–8 October 2023. Amsterdam, The Netherlands. Oral presentation.
5
EYLEA® 114.3 mg/mL Summary of Product Characteristics.
6
Lanzetta P, et al. Intravitreal aflibercept 8 mg injection in patients with neovascular age-related macular degeneration: 60-week and 96-week results from the Phase 3 PULSAR trial. EURETINA. 5–8 October 2023. Amsterdam, The Netherlands. Oral presentation.